Enterosgel

Updated June 29, 2026

Enterosgel is the brand name for polymethylsiloxane polyhydrate — a synthetic organosilicon compound supplied as a tasteless, odourless gel or paste. Despite the silicon connection, it is chemically distinct from silicon dioxide (the mineral silica) or diatomaceous earth. Its structure is a hydrated polymethylsiloxane matrix: a three-dimensional porous network of silicon-oxygen-carbon bonds that behaves like a molecular sieve in the gastrointestinal tract. Enterosgel has pharmaceutical status in Russia, Ukraine, Germany, and a growing number of European and Asian markets, where it is prescribed as an enterosorbent — a gut-based binder used to clear toxic and pathological compounds from the intestines.

What makes Enterosgel distinct from other gut binders is its selectivity. Activated charcoal adsorbs almost everything indiscriminately. Zeolite targets small ions. Enterosgel specifically captures organic molecules in the 100 to 1000 Dalton molecular weight range — the size range that includes bacterial endotoxins, bile acids, food allergens, histamine, products of intestinal fermentation, alcohol metabolites, and many drugs of abuse. Smaller molecules like vitamins, minerals, and electrolytes pass through largely unaffected. This makes it significantly more selective than charcoal and better suited for regular or cyclical use without depleting essential nutrients.

The clinical evidence base is more developed than most supplements in the binders category. A notable randomised controlled trial published in the British Medical Journal Open (2014) evaluated Enterosgel in diarrhoea-predominant IBS (IBS-D) and found significant reductions in stool frequency, urgency, and abdominal pain versus placebo over 8 weeks. The proposed mechanism — adsorption of bile acids and bacterial toxins that trigger hypermotility — is well-supported. Further trials in acute infectious diarrhea (particularly in children), food allergy symptoms, and alcohol-related gut inflammation show consistent benefit. Several studies from Russian and Ukrainian clinical settings document its use in managing gut-derived endotoxaemia and supporting liver detoxification pathways.

The gut permeability application is increasingly discussed in functional medicine. A damaged gut barrier allows bacterial lipopolysaccharides (LPS) — large endotoxins from gram-negative bacteria — to translocate into the bloodstream, driving systemic inflammation linked to metabolic syndrome, fatty liver, and chronic fatigue. Enterosgel’s adsorption of LPS in the gut lumen before absorption is the proposed mechanism for its broader systemic effects observed in some trials. This overlaps with the applications of zeolite and apple pectin, but with stronger human trial data.

Standard dosing is 15 g (one tablespoon of gel or one sachet) taken 1 to 2 hours before or after meals, two to three times daily for acute situations, or once daily for maintenance. It is tasteless and mixes easily with water. Like all binders, the timing rule is critical: take it well away from any medications or supplements you want absorbed. It is very well tolerated — constipation is the main side effect at higher doses, and it passes in stool without systemic absorption. It is safe for children (with dose adjustment) and has been used in pregnant women in clinical settings. This is general information, not medical advice.